Info
| Date | 25 May 1921 - 12 June 1921 |
| Discipline | Road |
| Category | 2.HC |
| Country |  Italy |
| Start | Milano |
| Finish | Milano |
| Distance | 3107.5 km |
Stages
| Stage | Date | Start | Finish |
|---|---|---|---|
| 1 | 25.05 | Milano | Merano |
| 2 | 27.05 | Merano | Bologna |
| 3 | 29.05 | Bologna | Perugia |
| 4 | 31.05 | Perugia | Chieti |
| 5 | 02.06 | Chieti | Napoli |
| 6 | 04.06 | Napoli | Roma |
| 7 | 06.06 | Roma | Livorno |
| 8 | 08.06 | Livorno | Parma |
| 9 | 10.06 | Parma | Torino |
| 10 | 12.06 | Torino | Milano |
Last winners
| 1921 | |
| 1920 | |
| 1919 | |
| 1914 | |
| 1913 | |
| 1911 | |
| 1910 | |
| 1909 |
