| Date | 05 March 2022 |
|---|---|
| Category | 1.WWT |
| Start | Siena |
| Finish | Siena |
| Distance | 136.0 km |
| Website | www.strade-bianche.it/en/ |
| 2022 | Lotte Kopecky |
| 2021 | Chantal Blaak-van den Broek |
| 2020 | Annemiek van Vleuten |
| 2019 | Annemiek van Vleuten |
| 2018 | Anna van der Breggen |
| 2017 | Elisa Longo Borghini |
| 2016 | Elizabeth Armitstead-Deignan |
| 2015 | Megan Guarnier |