| Date | 28 September 2021 - 01 October 2021 |
|---|---|
| Category | 2.1 |
| Start | Avola |
| Finish | Mascali |
| Distance | 712.0 km |
| Stage | Date | Start | Finish |
|---|---|---|---|
| 1 | 28.09 | Avola | Licata |
| 2 | 29.09 | Selinunte | Mondello |
| 3 | 30.09 | Termini Imerese | Caronia |
| 4 | 01.10 | Sant'Agata di Militello | Mascali |
| 2021 | Vincenzo Nibali |
| 2019 | Brandon McNulty |
| 1 | Vincenzo Nibali |
| 1 | Damiano Caruso |
| 1 | Alexey Lutsenko |
| 1 | Brandon McNulty |